Congratulations to successful PhD Defense Adrian Madarasz

On July 9, 2024, Adrian Madarasz, student of the Cutting Edge Microscopy (CEM) program under the supervision of Dr. Steven Proulx, has successfully defended his PhD thesis with the title: "Pathways and Dynamcis of Erythrocyte Efflux in Murine Models of Hemorrhagic Stroke".

During my PhD studies, I explored the involvement of the lymphatic system regarding the outflow of red blood cells (RBCs) in murine hemorrhagic stroke models. Employing newly developed labeling procedures for RBCs combined with epifluorescence in vivo imaging and 3D reconstructions from confocal microscopy of decalcified tissue, we have shown that the lymphatic vessels, especially in the cribriform plate region, contribute significantly to the clearance of RBCs from the subarachnoid space. Contrary to previous publications, access of RBCs to dorsal dural lymphatics was limited at early time points. In addition, we compared different models for intracerebral hemorrhage and their suitability for studying the efflux of cerebrospinal fluid or tracers from the subarachnoid space.